NGX

Nutrigenomics can be broadly described as the interaction between nutrition and our genes. We have the knowledge and ability to see how what we eat can affect our genes and how our genes can affect our bodies response to food. Certain foods, nutrients, vitamins, minerals, and other essential sources of nutrition are processed or metabolized based on the basic building blocks of our DNA called single nucleotide polymorphisms (SNPs).

SNPs are single-base pair variations that account for about 90%1 of all human genetic variation. Evaluating these SNPs can give valuable information on the amount of folate (a vitamin that assists in genomic stability) an individual should consume because of how their body processes or uses folate to convert homocysteine to methionine. This conversion utilizes folate in conjunction with other vitamins to complete the methylation process. Poor regulation of this biochemical process can result in symptoms such as fatigue, digestive issues, changes in mood, and hormone imbalance.

Buccal swabs and saliva are collected with easy-to-use sample kits provided by a vendor. A single swab or 2mL of saliva deposited directly into the collection tube, gives enough DNA to begin sequencing. Personalized Pediatrics Laboratories NGX assay uses next-generation sequencing (NGS), a molecular method that takes a patient’s DNA and breaks it up into smaller pieces for sequencing. Utilizing NGS allows us to cover all relevant genes while keeping costs affordable without sacrificing content or clinical utility.

A major benefit from our NGX assay is a better understanding of a patient’s nutritional needs that can directly affect prevention of chronic disease, such as obesity, diabetes, and cancer. Healthcare providers with the knowledge from NGX testing are better equipped in giving accurate recommendations for a diet that is specifically curated for an individual. This personalized method is the scientific way of debunking the one-size-fits-all approach that has discouraged many individuals who have not had positive experiences in a diet and lifestyle change. Patients who complete NGX testing live with a deeper understanding of their body and help them make more informed decisions about their health.